COVID-19 Progression Following Diagnosis
To interrogate how the immune system is altered from uninfected to mild to moderate to severe disease, we have characterized the circulating immune cell classes and collected plasma multi-omic profiles, on a cohort of 139 COVID-19 patients (265 samples) within the context of clinical observations, and compared them against 268 healthy donor samples. This view is built by first extracting the demographics and static and dynamic clinical features for each patient from their electronic health record (EHR). This clinical picture is then integrated with multi-omic analysis of two sequential blood draws per patient, the first of which was collected shortly after initial clinical diagnosis (time = T1), and the second a few days later (T2). For each blood draw, the plasma levels of around 500 proteins and 1000 metabolites were quantified along with single-cell multi-omic analyses of PBMCs in which whole transcriptome, 192 surface proteins, 32 secreted proteins, and T cell and B cell receptor gene sequences were measured.
Protein Coorelations By Group
Metabolite Coorelations By Group